منابع مشابه
Genomic research and incidental findings.
The Human Genome Project showed that there is significant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental findings create legal, ethical, and financial challenges for researchers. Current federal and internationa...
متن کاملIncidental Findings ? THE DUTY TO RESCUE IN GENOMIC RESEARCH
Gliwa et al. (2012) focus their analysis of researcher obligations for incidental findings in genomic research on three criteria: (1) the benefit to the research participant, which requires strong associations with severe disease that has medical actionability; (2) unique access to the information and analysis; and (3) the burden that looking and returning incidental findings places on the rese...
متن کاملIncidental findings in pediatric research.
The approach to incidental research findings in children emerges by considering the child-parent relationship and balancing divergent interests and preferences. Incidental findings with clear and proximate clinical importance should be disclosed to both. We recommend that particularly sensitive or private information (e.g., pregnancy or drug use) should be disclosed to the adolescent first, whi...
متن کاملGenomic test validation for incidental findings.
In March of 2013, the American College of Medical Genetics and Genomics (ACMG) issued recommendations for the reporting of incidental findings produced by clinical exome and genome sequencing (1, 2 ). This guideline on incidental findings has been controversial, because the recommendations are a departure from previous ethical concepts of patient autonomy and the reporting of adult-onset diseas...
متن کاملDefining and managing incidental findings in genetic and genomic practice.
The rapidly declining costs and increasing speeds of whole-genome analysis mean that genetic testing is undergoing a shift from targeted approaches to broader ones that look at the entire genome. As whole-genome technologies gain widespread use, questions about the management of so-called incidental findings-those unrelated to the question being asked-need urgent consideration. In this review, ...
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ژورنال
عنوان ژورنال: Journal of Law, Medicine & Ethics
سال: 2008
ISSN: 1073-1105,1748-720X
DOI: 10.1111/j.1748-720x.2008.00272.x